Fisetin induces DNA double-strand break and interferes with the repair of radiation-induced damage to radiosensitize triple negative breast cancer cells

Fisetin induces DNA double-strand break and interferes with the repair of radiation-induced damage to radiosensitize triple negative breast cancer cells

Abstract Background Triple-negative breast cancer (TNBC) is associated with aggressiveness and a poor prognosis. Besides surgery, radiotherapy serves as the major treatment modality for TNBC. However, response to radiotherapy is limited in many patients, most likely because of DNA damage response (D...

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Bibliographic Details
Main Authors: Shayan Khozooei, Konstanze Lettau, Francesca Barletta, Tina Jost, Simone Rebholz, Soundaram Veerappan, Mirita Franz-Wachtel, Boris Macek, George Iliakis, Luitpold V. Distel, Daniel Zips, Mahmoud Toulany
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Triple negative breast cancer
Y-box binding protein-1
Fisetin
Double strand break repair
Radiosensitization
Online Access:https://doi.org/10.1186/s13046-022-02442-x

Internet

https://doi.org/10.1186/s13046-022-02442-x

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