Simvastatin and oxidative stress in humans: A randomized, double-blinded, placebo-controlled clinical trial

Simvastatin and oxidative stress in humans: A randomized, double-blinded, placebo-controlled clinical trial

Simvastatin reduces the blood concentration of cholesterol by inhibiting hydroxymethylglutaryl-coenzyme A reductase, the rate-limiting enzyme in cholesterol synthesis, and thereby reduces the risk of cardiovascular disease. In addition, simvastatin treatment leads to a reduction in fluxes in mitocho...

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Bibliographic Details
Main Authors: Sanne Tofte Rasmussen, Jon Trærup Andersen, Torben Kjær Nielsen, Vanja Cejvanovic, Kasper Meidahl Petersen, Trine Henriksen, Allan Weimann, Jens Lykkesfeldt, Henrik Enghusen Poulsen
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Redox Biology
Subjects:
Simvastatin
Randomized clinical trial
Oxidative stress
Reactive oxygen species
8-oxodg
8-oxoguo
DNA oxidation
RNA oxidation
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231716300398

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http://www.sciencedirect.com/science/article/pii/S2213231716300398

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