Nucleophosmin 1 cooperates with the methyltransferase DOT1L to preserve peri-nucleolar heterochromatin organization by regulating H3K27me3 levels and DNA repeats expression

Nucleophosmin 1 cooperates with the methyltransferase DOT1L to preserve peri-nucleolar heterochromatin organization by regulating H3K27me3 levels and DNA repeats expression

Abstract Background NPM1 is a phosphoprotein highly abundant in the nucleolus. However, additional nuclear functions have been attributed to NPM1, probably through interaction with other nuclear factors. DOT1L is one interaction partner of NPM1 that catalyzes methylation of histone H3 at lysine 79 (...

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Bibliographic Details
Main Authors: Annalisa Izzo, Ipek Akol, Alejandro Villarreal, Shannon Lebel, Marta Garcia-Miralles, Arquimedes Cheffer, Patrick Bovio, Stefanie Heidrich, Tanja Vogel
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Epigenetics & Chromatin
Subjects:
DOT1L
NPM1
Histone methylation
Peri-nucleolar heterochromatin
Transcription
Epigenetics
Online Access:https://doi.org/10.1186/s13072-023-00511-9

Internet

https://doi.org/10.1186/s13072-023-00511-9

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