Introduction of Mutant GNAQ into Endothelial Cells Induces a Vascular Malformation Phenotype with Therapeutic Response to Imatinib

Introduction of Mutant GNAQ into Endothelial Cells Induces a Vascular Malformation Phenotype with Therapeutic Response to Imatinib

GNAQ is mutated in vascular and melanocytic lesions, including vascular malformations and nevi. No in vivo model of GNAQ activation in endothelial cells has previously been described. We introduce mutant GNAQ into a murine endothelial cell line, MS1. The resultant transduced cells exhibit a novel ph...

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Bibliographic Details
Main Authors: Maiko Sasaki, Yoonhee Jung, Paula North, Justin Elsey, Keith Choate, Michael Andrew Toussaint, Christina Huang, Rakan Radi, Adam J. Perricone, Victor G. Corces, Jack L. Arbiser
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cancers
Subjects:
GNAQ
vascular malformation
endothelial cells
Sturge Weber
vasculogenesis
Online Access:https://www.mdpi.com/2072-6694/14/2/413

Internet

https://www.mdpi.com/2072-6694/14/2/413

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