Androgen suppresses the proliferation of androgen receptor-positive castration-resistant prostate cancer cells via inhibition of Cdk2, CyclinA, and Skp2.

Androgen suppresses the proliferation of androgen receptor-positive castration-resistant prostate cancer cells via inhibition of Cdk2, CyclinA, and Skp2.

The majority of prostate cancer (PCa) patient receiving androgen ablation therapy eventually develop castration-resistant prostate cancer (CRPC). We previously reported that androgen treatment suppresses Skp2 and c-Myc through androgen receptor (AR) and induced G1 cell cycle arrest in androgen-indep...

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Bibliographic Details
Main Authors: John M Kokontis, Hui-Ping Lin, Shih Sheng Jiang, Ching-Yu Lin, Junichi Fukuchi, Richard A Hiipakka, Chi-Jung Chung, Tzu-Min Chan, Shutsung Liao, Chung-Ho Chang, Chih-Pin Chuu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4182885?pdf=render

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http://europepmc.org/articles/PMC4182885?pdf=render

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