Serum differential proteomic profiling of patients with isolated methylmalonic acidemia by iTRAQ

Serum differential proteomic profiling of patients with isolated methylmalonic acidemia by iTRAQ

Isolated methylmalonic acidemia (MMA) is an inherited organic acid metabolic disorder in an autosomal recessive manner, caused by mutations in the methylmalonyl coenzyme A mutase gene, and the isolated MMA patients often suffer from multi-organ damage. The present study aimed to profile the differen...

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Bibliographic Details
Main Authors: Sitao Li, Congcong Shi, Yao Cai, Xia Gu, Hui Xiong, Xiaoyu Liu, Yinchun Zhang, Xin Xiao, Fei Ma, Hu Hao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Genetics
Subjects:
methylmalonic acidemia
iTRAQ
differential proteome
cholesterol metabolism
immunoglobulins
methylmalonyl coenzyme A mutase
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.765637/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.765637/full

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