The Endothelial Glycocalyx as a Target of Excess Soluble Fms-like Tyrosine Kinase-1

The Endothelial Glycocalyx as a Target of Excess Soluble Fms-like Tyrosine Kinase-1

Soluble fms-like tyrosine kinase-1 (sFlt-1) is a secreted protein that binds heparan sulfate expressed on the endothelial glycocalyx (eGC). In this paper we analyze how excess sFlt-1 causes conformational changes in the eGC, leading to monocyte adhesion, a key event triggering vascular dysfunction....

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Bibliographic Details
Main Authors: Annika Schulz, Carolin C. Drost, Bettina Hesse, Katrin Beul, Göran R. Boeckel, Alexander Lukasz, Hermann Pavenstädt, Marcus Brand, Giovana S. Di Marco
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
endothelial glycocalyx
soluble fms-like tyrosine kinase-1 (sFlt-1)
heparin
endothelial dysfunction
endothelial injury
monocyte adhesion
Online Access:https://www.mdpi.com/1422-0067/24/6/5380

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https://www.mdpi.com/1422-0067/24/6/5380

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