PTPN2 Is a Critical Regulator of Ileal Paneth Cell Viability and Function in MiceSummary

PTPN2 Is a Critical Regulator of Ileal Paneth Cell Viability and Function in MiceSummary

Background & Aims: Loss-of-function variants in the PTPN2 gene are associated with increased risk of inflammatory bowel disease. We recently showed that Ptpn2 is critical for intestinal epithelial cell (IEC) barrier maintenance, IEC–macrophage communication, and modulation of the gut microbi...

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Bibliographic Details
Main Authors: Vinicius Canale, Marianne R. Spalinger, Rocio Alvarez, Anica Sayoc-Becerra, Golshid Sanati, Salomon Manz, Pritha Chatterjee, Alina N. Santos, Hillmin Lei, Sharon Jahng, Timothy Chu, Ali Shawki, Elaine Hanson, Lars Eckmann, André J. Ouellette, Declan F. McCole
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Antimicrobial Peptides
TCPTP
Lysozyme
Intestinal Epithelial Cells
Inflammatory Bowel Disease
Microbiome
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X23000498

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http://www.sciencedirect.com/science/article/pii/S2352345X23000498

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