Paradoxical activation of chronic lymphocytic leukemia cells by ruxolitinib in vitro and in vivo

Paradoxical activation of chronic lymphocytic leukemia cells by ruxolitinib in vitro and in vivo

IntroductionChronic lymphocytic leukemia (CLL) is characterized by an aberrant cytokine network that can support tumor growth by triggering janus kinase (JAK)/STAT pathways. Targeting cytokine-signaling should then be a rational therapeutic strategy but the JAK inhibitor ruxolitinib failed to contro...

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Bibliographic Details
Main Authors: David E. Spaner, Tina YuXuan Luo, Guizhi Wang, Gideon Schreiber, Daniel Harari, Yonghong Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Oncology
Subjects:
Chronic lymphocytic leukemia
IL-10
cytokines
toll-like receptors
janus kinases
cancer microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1043694/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1043694/full

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