Toxic Effects of Indoxyl Sulfate on Osteoclastogenesis and Osteoblastogenesis

Uremic toxins, such as indoxyl sulfate (IS) and kynurenine, accumulate in the blood in the event of kidney failure and contribute to further bone damage. To maintain the homeostasis of the skeletal system, bone remodeling is a persistent process of bone formation and bone resorption that depends on...

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Bibliographic Details
Main Authors: Jia-Fwu Shyu, Wen-Chih Liu, Cai-Mei Zheng, Te-Chao Fang, Yi-Chou Hou, Chiz-Tzung Chang, Ting-Ying Liao, Yin-Cheng Chen, Kuo-Cheng Lu
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/22/20/11265