Modelling the effects of elevated methylglyoxal levels on vascular and metabolic complications

Modelling the effects of elevated methylglyoxal levels on vascular and metabolic complications

Abstract Methylglyoxal (MGO), a glycolysis by-product and precursor to advanced glycation endproducts (AGEs), is associated with glucose intolerance, type 2 diabetes, and vascular dysfunction. This study examined the long-term effects of elevated MGO on blood pressure, insulin sensitivity, and vascu...

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Bibliographic Details
Main Authors: Philippe Vangrieken, Jean L. J. M. Scheijen, Paul M. H. Schiffers, Marjo P. H. van de Waarenburg, Sebastien Foulquier, Casper C. G. Schalkwijk
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Methylglyoxal
Advanced glycation endproducts
Diabetes
Hypertension
Insulin resistance
Metabolic toxicity
Online Access:https://doi.org/10.1038/s41598-025-90661-5

Internet

https://doi.org/10.1038/s41598-025-90661-5

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