Correlation of plasma concentration and adverse effects of bosutinib: standard dose or dose-escalation regimens of bosutinib treatment for patients with chronic myeloid leukemia

Correlation of plasma concentration and adverse effects of bosutinib: standard dose or dose-escalation regimens of bosutinib treatment for patients with chronic myeloid leukemia

Abstract Purpose To investigate the exposure-toxicity relationship of bosutinib and to identify the target trough plasma concentration (C0). Methods The toxicity and C0 of bosutinib in Japanese chronic myeloid leukemia (CML) patients were monitored every 2 weeks for the first 3 months of treatment,...

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Bibliographic Details
Main Authors: Akiko Mita, Maiko Abumiya, Masatomo Miura, Takenori Niioka, Saori Takahashi, Tomoko Yoshioka, Yoshihiro Kameoka, Naoto Takahashi
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Experimental Hematology & Oncology
Subjects:
Bosutinib
Diarrhea
Liver dysfunction
Trough concentration
Chronic myeloid leukemia
Online Access:http://link.springer.com/article/10.1186/s40164-018-0101-1

Internet

http://link.springer.com/article/10.1186/s40164-018-0101-1

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