Migration deficits of the neural crest caused by CXADR triplication in a human Down syndrome stem cell model

Migration deficits of the neural crest caused by CXADR triplication in a human Down syndrome stem cell model

Abstract Down syndrome (DS) is the most common chromosomal abnormality in live-born infants and is caused by trisomy of chromosome 21. Most individuals with DS display craniofacial dysmorphology, including reduced sizes of the skull, maxilla, and mandible. However, the underlying pathogenesis remain...

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Bibliographic Details
Main Authors: Huanyao Liu, Shanshan Huang, Weijia Wang, Huiyan Wang, Weijun Huang, Zhichen Zhai, Ding Wang, Yubao Fan, Jiaqi Sun, Dairui Li, Weicheng Chiu, Xingqiang Lai, Jixiao Zeng, Qiong Ke, Tao Wang, Andy Peng Xiang, Yong Yuan, Xinchun Zhang, Weiqiang Li
Format: Article
Language:English
Published: Nature Publishing Group 2022-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05481-6

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https://doi.org/10.1038/s41419-022-05481-6

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