High matrix stiffness accelerates migration of hepatocellular carcinoma cells through the integrin β1-Plectin-F-actin axis

High matrix stiffness accelerates migration of hepatocellular carcinoma cells through the integrin β1-Plectin-F-actin axis

Abstract Background Abundant research indicates that increased extracellular matrix (ECM) stiffness significantly enhances the malignant characteristics of hepatocellular carcinoma (HCC) cells. Plectin, an essential cytoskeletal linker protein, has recently emerged as a promoter of cancer progressio...

Full description

Bibliographic Details
Main Authors: Zhihui Wang, Wenbin Wang, Qing Luo, Guanbin Song
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Biology
Subjects:
Matrix stiffness
Hepatocellular carcinoma
Plectin
Integrin β1
F-actin
Cell migration
Online Access:https://doi.org/10.1186/s12915-025-02113-1

Internet

https://doi.org/10.1186/s12915-025-02113-1

Similar Items