The interface between methyltransferase and polymerase of NS5 is essential for flavivirus replication.

The interface between methyltransferase and polymerase of NS5 is essential for flavivirus replication.

The flavivirus NS5 harbors both a methyltransferase (MTase) and an RNA-dependent RNA polymerase (RdRP). Both enzyme activities of NS5 are critical for viral replication. Recently, the full-length NS5 crystal structure of Japanese encephalitis virus reveals a conserved MTase-RdRP interface that featu...

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Bibliographic Details
Main Authors: Xiao-Dan Li, Chao Shan, Cheng-Lin Deng, Han-Qing Ye, Pei-Yong Shi, Zhi-Ming Yuan, Peng Gong, Bo Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-05-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4031075?pdf=render

Internet

http://europepmc.org/articles/PMC4031075?pdf=render

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