Modulation of Plasma Lipidomic Profiles in Metastatic Castration-Resistant Prostate Cancer by Simvastatin

Modulation of Plasma Lipidomic Profiles in Metastatic Castration-Resistant Prostate Cancer by Simvastatin

Elevated circulating sphingolipids are associated with shorter overall survival and therapeutic resistance in metastatic castration-resistant prostate cancer (mCRPC), suggesting that perturbations in sphingolipid metabolism promotes prostate cancer growth. This study assessed whether addition of sim...

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Bibliographic Details
Main Authors: Blossom Mak, Hui-Ming Lin, Thy Duong, Kate L. Mahon, Anthony M. Joshua, Martin R. Stockler, Howard Gurney, Francis Parnis, Alison Zhang, Tahlia Scheinberg, Gary Wittert, Lisa M. Butler, David Sullivan, Andrew J. Hoy, Peter J. Meikle, Lisa G. Horvath
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cancers
Subjects:
ceramides
metabolic therapy
lipidomic
prostate cancer
sphingolipids
statins
Online Access:https://www.mdpi.com/2072-6694/14/19/4792

Internet

https://www.mdpi.com/2072-6694/14/19/4792

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