Endothelial Mechanistic Target of Rapamycin Activation with Different Strains of <i>R. rickettsii</i>: Possible Role in Rickettsial Pathogenesis

Endothelial Mechanistic Target of Rapamycin Activation with Different Strains of <i>R. rickettsii</i>: Possible Role in Rickettsial Pathogenesis

<i>Rickettsia rickettsii</i> is an obligate intracellular pathogen that primarily targets endothelial cells (ECs), leading to vascular inflammation and dysfunction. Mechanistic target of rapamycin (mTOR) regulates several cellular processes that directly affect host immune responses to b...

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Bibliographic Details
Main Authors: Abha Sahni, Jessica Alsing, Hema P. Narra, Michelle Montini, Yasim Zafar, Sanjeev K. Sahni
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Microorganisms
Subjects:
endothelial cells
mTOR
<i>Rickettsia</i>
autophagy
inflammation
Online Access:https://www.mdpi.com/2076-2607/12/2/296

Internet

https://www.mdpi.com/2076-2607/12/2/296

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