Transmembrane and ubiquitin-like domain containing 1 (Tmub1) regulates locomotor activity and wakefulness in mice and interacts with CAMLG.

Transmembrane and ubiquitin-like domain containing 1 (Tmub1) regulates locomotor activity and wakefulness in mice and interacts with CAMLG.

Tmub1 (C7orf21/HOPS) encodes a protein containing a ubiquitin-like domain. Tmub1 is highly expressed in the nervous system. To study its physiological function, we generated mice with Tmub1 deleted by homologous recombination. The knockout mice were grossly normal and viable. In a comprehensive beha...

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Bibliographic Details
Main Authors: Wandong Zhang, Katerina V Savelieva, Adisak Suwanichkul, Daniel L Small, Laura L Kirkpatrick, Nianhua Xu, Thomas H Lanthorn, Gui-Lan Ye
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2889838?pdf=render

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http://europepmc.org/articles/PMC2889838?pdf=render

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