Natural carboxyterminal truncation of human CXCL10 attenuates glycosaminoglycan binding, CXCR3A signaling and lymphocyte chemotaxis, while retaining angiostatic activity

Natural carboxyterminal truncation of human CXCL10 attenuates glycosaminoglycan binding, CXCR3A signaling and lymphocyte chemotaxis, while retaining angiostatic activity

Abstract Background Interferon-γ-inducible protein of 10 kDa (IP-10/CXCL10) is a dual-function CXC chemokine that coordinates chemotaxis of activated T cells and natural killer (NK) cells via interaction with its G protein-coupled receptor (GPCR), CXC chemokine receptor 3 (CXCR3). As a consequence o...

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Bibliographic Details
Main Authors: Luna Dillemans, Karen Yu, Alexandra De Zutter, Sam Noppen, Mieke Gouwy, Nele Berghmans, Lisa Verhallen, Mirre De Bondt, Lotte Vanbrabant, Stef Brusselmans, Erik Martens, Dominique Schols, Patrick Verschueren, Mette M. Rosenkilde, Pedro Elias Marques, Sofie Struyf, Paul Proost
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Cell Communication and Signaling
Subjects:
Angiogenesis
Chemokine
CXCL10
Lymphocytes
Posttranslational modifications
Proteolysis
Online Access:https://doi.org/10.1186/s12964-023-01453-1

Internet

https://doi.org/10.1186/s12964-023-01453-1

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