IgG4 glycosylation contributes to the pathogenesis of IgG4 Hashimoto’s thyroiditis via the complement pathway

IgG4 glycosylation contributes to the pathogenesis of IgG4 Hashimoto’s thyroiditis via the complement pathway

Background: To explore whether IgG4 is involved in the pathogenesis of IgG4 HT. Methods: Serum TgAb IgG4 and TPOAb IgG4 were measured in IgG4 HT and non-IgG4 HT. C1q, mannose-binding lectin (MBL), Bb, C3d, C4d, and membrane attack complex (MAC) in thyroid tissues from IgG4 HT, non-IgG4 HT, and con...

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Bibliographic Details
Main Authors: Chenxu Zhao, Zhiming Sun, Shuaihang Wang, Jixin Zhang, Jumei Liu, Lei Chen, Guizhi Lu, Yang Yu, Ying Gao
Format: Article
Language:English
Published: Bioscientifica 2024-10-01
Series:European Thyroid Journal
Subjects:
complement activation
glycosylation
igg4 antibody
igg4 ht
pathogenesis
Online Access:https://etj.bioscientifica.com/view/journals/etj/13/5/ETJ-24-0156.xml

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https://etj.bioscientifica.com/view/journals/etj/13/5/ETJ-24-0156.xml

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