Distinct Nuclear Organization of Telomeres and Centromeres in Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma
Both multiple myeloma (MM) and its precursor state of monoclonal gammopathy of undetermined significance (MGUS) are characterized by an infiltration of plasma cells into the bone marrow, but the mechanisms underlying the disease progression remain poorly understood. Previous research has indicated t...
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MDPI AG
2019-07-01
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Online Access: | https://www.mdpi.com/2073-4409/8/7/723 |
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author | Pak Lok Ivan Yu Rachel R. Wang Grace Johnston Yaqiong Wang Pille Tammur Anu Tamm Mari Punab Aline Rangel-Pozzo Sabine Mai |
author_facet | Pak Lok Ivan Yu Rachel R. Wang Grace Johnston Yaqiong Wang Pille Tammur Anu Tamm Mari Punab Aline Rangel-Pozzo Sabine Mai |
author_sort | Pak Lok Ivan Yu |
collection | DOAJ |
description | Both multiple myeloma (MM) and its precursor state of monoclonal gammopathy of undetermined significance (MGUS) are characterized by an infiltration of plasma cells into the bone marrow, but the mechanisms underlying the disease progression remain poorly understood. Previous research has indicated that 3D nuclear telomeric and centromeric organization may represent important structural indicators for numerous malignancies. Here we corroborate with previously noted differences in the 3D telomeric architecture and report that modifications in the nuclear distribution of centromeres may serve as a novel structural marker with potential to distinguish MM from MGUS. Our findings improve the current characterization of the two disease stages, providing two structural indicators that may become altered in the progression of MGUS to MM. |
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institution | Directory Open Access Journal |
issn | 2073-4409 |
language | English |
last_indexed | 2024-03-12T19:43:15Z |
publishDate | 2019-07-01 |
publisher | MDPI AG |
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spelling | doaj.art-63275a6ea489445ebfe908c058fbca0b2023-08-02T03:41:41ZengMDPI AGCells2073-44092019-07-018772310.3390/cells8070723cells8070723Distinct Nuclear Organization of Telomeres and Centromeres in Monoclonal Gammopathy of Undetermined Significance and Multiple MyelomaPak Lok Ivan Yu0Rachel R. Wang1Grace Johnston2Yaqiong Wang3Pille Tammur4Anu Tamm5Mari Punab6Aline Rangel-Pozzo7Sabine Mai8Cell Biology, Research Institute of Oncology and Hematology, University of Manitoba, CancerCare Manitoba, Winnipeg, MB R3C 2B7, CanadaCell Biology, Research Institute of Oncology and Hematology, University of Manitoba, CancerCare Manitoba, Winnipeg, MB R3C 2B7, CanadaCell Biology, Research Institute of Oncology and Hematology, University of Manitoba, CancerCare Manitoba, Winnipeg, MB R3C 2B7, CanadaCell Biology, Research Institute of Oncology and Hematology, University of Manitoba, CancerCare Manitoba, Winnipeg, MB R3C 2B7, CanadaUnited Laboratories, Tartu University Hospital, 50406 Tartu, EstoniaUnited Laboratories, Tartu University Hospital, 50406 Tartu, EstoniaDepartment of Haematology and Bone Marrow Transplantation, Clinic of Haematology and Oncology, Tartu University Hospital, 50406 Tartu, EstoniaCell Biology, Research Institute of Oncology and Hematology, University of Manitoba, CancerCare Manitoba, Winnipeg, MB R3C 2B7, CanadaCell Biology, Research Institute of Oncology and Hematology, University of Manitoba, CancerCare Manitoba, Winnipeg, MB R3C 2B7, CanadaBoth multiple myeloma (MM) and its precursor state of monoclonal gammopathy of undetermined significance (MGUS) are characterized by an infiltration of plasma cells into the bone marrow, but the mechanisms underlying the disease progression remain poorly understood. Previous research has indicated that 3D nuclear telomeric and centromeric organization may represent important structural indicators for numerous malignancies. Here we corroborate with previously noted differences in the 3D telomeric architecture and report that modifications in the nuclear distribution of centromeres may serve as a novel structural marker with potential to distinguish MM from MGUS. Our findings improve the current characterization of the two disease stages, providing two structural indicators that may become altered in the progression of MGUS to MM.https://www.mdpi.com/2073-4409/8/7/723multiple myelomamonoclonal gammopathy of undetermined significancetelomerescentromeresstructural genome markersgenomic instability |
spellingShingle | Pak Lok Ivan Yu Rachel R. Wang Grace Johnston Yaqiong Wang Pille Tammur Anu Tamm Mari Punab Aline Rangel-Pozzo Sabine Mai Distinct Nuclear Organization of Telomeres and Centromeres in Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma Cells multiple myeloma monoclonal gammopathy of undetermined significance telomeres centromeres structural genome markers genomic instability |
title | Distinct Nuclear Organization of Telomeres and Centromeres in Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma |
title_full | Distinct Nuclear Organization of Telomeres and Centromeres in Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma |
title_fullStr | Distinct Nuclear Organization of Telomeres and Centromeres in Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma |
title_full_unstemmed | Distinct Nuclear Organization of Telomeres and Centromeres in Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma |
title_short | Distinct Nuclear Organization of Telomeres and Centromeres in Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma |
title_sort | distinct nuclear organization of telomeres and centromeres in monoclonal gammopathy of undetermined significance and multiple myeloma |
topic | multiple myeloma monoclonal gammopathy of undetermined significance telomeres centromeres structural genome markers genomic instability |
url | https://www.mdpi.com/2073-4409/8/7/723 |
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