Synthesis and Effect of Conformationally Locked Carbocyclic Guanine Nucleotides on Dynamin

Synthesis and Effect of Conformationally Locked Carbocyclic Guanine Nucleotides on Dynamin

Guanine nucleotides can flip between a North and South conformation in the ribose moiety. To test the enzymatic activity of GTPases bound to nucleotides in the two conformations, we generated methanocarba guanine nucleotides in the North or South envelope conformations, i.e., (N)-GTP and (S)-GTP, re...

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Bibliographic Details
Main Authors: Kiran S. Toti, John R. Jimah, Veronica Salmaso, Jenny E. Hinshaw, Kenneth A. Jacobson
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Biomolecules
Subjects:
conformationally locked
methanocarba
guanine nucleotide
dynamin
GTPase
membrane fission
Online Access:https://www.mdpi.com/2218-273X/12/4/584

Internet

https://www.mdpi.com/2218-273X/12/4/584

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