Helicobacter pylori Vacuolating Toxin and Gastric Cancer
Helicobacter pylori VacA is a channel-forming toxin unrelated to other known bacterial toxins. Most H. pylori strains contain a vacA gene, but there is marked variation among strains in VacA toxin activity. This variation is attributable to strain-specific variations in VacA amino acid sequences, as...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-10-01
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| Series: | Toxins |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6651/9/10/316 |
| _version_ | 1828117732897325056 |
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| author | Mark S. McClain Amber C. Beckett Timothy L. Cover |
| author_facet | Mark S. McClain Amber C. Beckett Timothy L. Cover |
| author_sort | Mark S. McClain |
| collection | DOAJ |
| description | Helicobacter pylori VacA is a channel-forming toxin unrelated to other known bacterial toxins. Most H. pylori strains contain a vacA gene, but there is marked variation among strains in VacA toxin activity. This variation is attributable to strain-specific variations in VacA amino acid sequences, as well as variations in the levels of VacA transcription and secretion. In this review, we discuss epidemiologic studies showing an association between specific vacA allelic types and gastric cancer, as well as studies that have used animal models to investigate VacA activities relevant to gastric cancer. We also discuss the mechanisms by which VacA-induced cellular alterations may contribute to the pathogenesis of gastric cancer. |
| first_indexed | 2024-04-11T13:19:11Z |
| format | Article |
| id | doaj.art-632c0f2f9c59489cab0382bce523513e |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-11T13:19:11Z |
| publishDate | 2017-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-632c0f2f9c59489cab0382bce523513e2022-12-22T04:22:16ZengMDPI AGToxins2072-66512017-10-0191031610.3390/toxins9100316toxins9100316Helicobacter pylori Vacuolating Toxin and Gastric CancerMark S. McClain0Amber C. Beckett1Timothy L. Cover2Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USADepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USADepartment of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USAHelicobacter pylori VacA is a channel-forming toxin unrelated to other known bacterial toxins. Most H. pylori strains contain a vacA gene, but there is marked variation among strains in VacA toxin activity. This variation is attributable to strain-specific variations in VacA amino acid sequences, as well as variations in the levels of VacA transcription and secretion. In this review, we discuss epidemiologic studies showing an association between specific vacA allelic types and gastric cancer, as well as studies that have used animal models to investigate VacA activities relevant to gastric cancer. We also discuss the mechanisms by which VacA-induced cellular alterations may contribute to the pathogenesis of gastric cancer.https://www.mdpi.com/2072-6651/9/10/316Helicobacter pylorigastric cancerpore-forming toxins |
| spellingShingle | Mark S. McClain Amber C. Beckett Timothy L. Cover Helicobacter pylori Vacuolating Toxin and Gastric Cancer Toxins Helicobacter pylori gastric cancer pore-forming toxins |
| title | Helicobacter pylori Vacuolating Toxin and Gastric Cancer |
| title_full | Helicobacter pylori Vacuolating Toxin and Gastric Cancer |
| title_fullStr | Helicobacter pylori Vacuolating Toxin and Gastric Cancer |
| title_full_unstemmed | Helicobacter pylori Vacuolating Toxin and Gastric Cancer |
| title_short | Helicobacter pylori Vacuolating Toxin and Gastric Cancer |
| title_sort | helicobacter pylori vacuolating toxin and gastric cancer |
| topic | Helicobacter pylori gastric cancer pore-forming toxins |
| url | https://www.mdpi.com/2072-6651/9/10/316 |
| work_keys_str_mv | AT marksmcclain helicobacterpylorivacuolatingtoxinandgastriccancer AT ambercbeckett helicobacterpylorivacuolatingtoxinandgastriccancer AT timothylcover helicobacterpylorivacuolatingtoxinandgastriccancer |