Structure and Diversity of the Rhesus Macaque Immunoglobulin Loci through Multiple De Novo Genome Assemblies

Structure and Diversity of the Rhesus Macaque Immunoglobulin Loci through Multiple De Novo Genome Assemblies

The rhesus macaque is a critically important animal model in biomedical research, most recently playing a key role in the development of vaccines against human immunodeficiency virus-1. Nevertheless, the immunoglobulin (Ig) loci of macaques are as yet incompletely determined and our understanding of...

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Bibliographic Details
Main Authors: Akshaya Ramesh, Sam Darko, Axin Hua, Glenn Overman, Amy Ransier, Joseph R. Francica, Ashley Trama, Georgia D. Tomaras, Barton F. Haynes, Daniel C. Douek, Thomas B. Kepler
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
rhesus macaque
immunoglobulin
allelic diversity
high-throughput sequencing
evolution
vaccine
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01407/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01407/full

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