Blood Catalase, Superoxide Dismutase, and Glutathione Peroxidase Activities in Alcohol- and Opioid-Addicted Patients
<i>Background and Objectives</i>: Multiple evaluations of oxidative stress in individuals with substance use disorder show elevated levels compared to non-substance-abusing individuals. Information concerning antioxidant defense mechanisms in relation to alcohol and opioid dependence is...
| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
MDPI AG
2025-01-01
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| coleção: | Medicina |
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| Acesso em linha: | https://www.mdpi.com/1648-9144/61/2/204 |
| _version_ | 1826581997928054784 |
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| author | Nino Asatiani Nelly Sapojnikova Tamar Kartvelishvili Lali Asanishvili Nestan Sichinava Zaza Chikovani |
| author_facet | Nino Asatiani Nelly Sapojnikova Tamar Kartvelishvili Lali Asanishvili Nestan Sichinava Zaza Chikovani |
| author_sort | Nino Asatiani |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Multiple evaluations of oxidative stress in individuals with substance use disorder show elevated levels compared to non-substance-abusing individuals. Information concerning antioxidant defense mechanisms in relation to alcohol and opioid dependence is variable and sometimes contradictory. The objective of the present investigation was to identify and compare several antioxidants in plasma during distinct phases of alcohol and opioid dependency (intoxication and withdrawal). <i>Materials and Methods</i>: This case study focuses on individuals with opioid and alcohol addiction. We recruited 80 participants (males aged 40 ± 10 years) and equally divided them into two categories: those with alcohol addiction and those with opioid addiction. A control group consisted of 20 healthy adults (males aged 35 ± 10 years). The spectrophotometric methods were used to quantify catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPx) activity in plasma. Antioxidant values were analyzed between groups using pairwise Mann–Whitney tests. <i>Results</i>: During withdrawal from alcohol and opioids, catalase activity tends to decrease compared to intoxication. The overall activity of superoxide dismutase exhibited an increase during alcohol intoxication and withdrawal and a reduction during opioid withdrawal compared to the intoxication phase. Both alcohol and opioids reduced plasma GPx activity in withdrawal cases, although the extent of this decrease varied considerably. <i>Conclusions</i>: The study confirms the valuable impact of addiction on the organism’s oxidative stress and reveals various behaviors of antioxidant defense enzymes during intoxication and withdrawal phases. |
| first_indexed | 2025-03-14T14:58:58Z |
| format | Article |
| id | doaj.art-633df7174ab04cb18f5b189c8bad8a71 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2025-03-14T14:58:58Z |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-633df7174ab04cb18f5b189c8bad8a712025-02-25T13:37:22ZengMDPI AGMedicina1010-660X1648-91442025-01-0161220410.3390/medicina61020204Blood Catalase, Superoxide Dismutase, and Glutathione Peroxidase Activities in Alcohol- and Opioid-Addicted PatientsNino Asatiani0Nelly Sapojnikova1Tamar Kartvelishvili2Lali Asanishvili3Nestan Sichinava4Zaza Chikovani5Elevter Andronikashvili Institute of Physics, Ivane Javakhishvili Tbilisi State University, Tbilisi 0179, GeorgiaElevter Andronikashvili Institute of Physics, Ivane Javakhishvili Tbilisi State University, Tbilisi 0179, GeorgiaElevter Andronikashvili Institute of Physics, Ivane Javakhishvili Tbilisi State University, Tbilisi 0179, GeorgiaElevter Andronikashvili Institute of Physics, Ivane Javakhishvili Tbilisi State University, Tbilisi 0179, GeorgiaNarcological Clinic “Nishati”, Tbilisi 0186, GeorgiaNarcological Clinic “Nishati”, Tbilisi 0186, Georgia<i>Background and Objectives</i>: Multiple evaluations of oxidative stress in individuals with substance use disorder show elevated levels compared to non-substance-abusing individuals. Information concerning antioxidant defense mechanisms in relation to alcohol and opioid dependence is variable and sometimes contradictory. The objective of the present investigation was to identify and compare several antioxidants in plasma during distinct phases of alcohol and opioid dependency (intoxication and withdrawal). <i>Materials and Methods</i>: This case study focuses on individuals with opioid and alcohol addiction. We recruited 80 participants (males aged 40 ± 10 years) and equally divided them into two categories: those with alcohol addiction and those with opioid addiction. A control group consisted of 20 healthy adults (males aged 35 ± 10 years). The spectrophotometric methods were used to quantify catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPx) activity in plasma. Antioxidant values were analyzed between groups using pairwise Mann–Whitney tests. <i>Results</i>: During withdrawal from alcohol and opioids, catalase activity tends to decrease compared to intoxication. The overall activity of superoxide dismutase exhibited an increase during alcohol intoxication and withdrawal and a reduction during opioid withdrawal compared to the intoxication phase. Both alcohol and opioids reduced plasma GPx activity in withdrawal cases, although the extent of this decrease varied considerably. <i>Conclusions</i>: The study confirms the valuable impact of addiction on the organism’s oxidative stress and reveals various behaviors of antioxidant defense enzymes during intoxication and withdrawal phases.https://www.mdpi.com/1648-9144/61/2/204alcoholopioidscatalasesuperoxide dismutaseglutathione peroxidaseintoxication |
| spellingShingle | Nino Asatiani Nelly Sapojnikova Tamar Kartvelishvili Lali Asanishvili Nestan Sichinava Zaza Chikovani Blood Catalase, Superoxide Dismutase, and Glutathione Peroxidase Activities in Alcohol- and Opioid-Addicted Patients Medicina alcohol opioids catalase superoxide dismutase glutathione peroxidase intoxication |
| title | Blood Catalase, Superoxide Dismutase, and Glutathione Peroxidase Activities in Alcohol- and Opioid-Addicted Patients |
| title_full | Blood Catalase, Superoxide Dismutase, and Glutathione Peroxidase Activities in Alcohol- and Opioid-Addicted Patients |
| title_fullStr | Blood Catalase, Superoxide Dismutase, and Glutathione Peroxidase Activities in Alcohol- and Opioid-Addicted Patients |
| title_full_unstemmed | Blood Catalase, Superoxide Dismutase, and Glutathione Peroxidase Activities in Alcohol- and Opioid-Addicted Patients |
| title_short | Blood Catalase, Superoxide Dismutase, and Glutathione Peroxidase Activities in Alcohol- and Opioid-Addicted Patients |
| title_sort | blood catalase superoxide dismutase and glutathione peroxidase activities in alcohol and opioid addicted patients |
| topic | alcohol opioids catalase superoxide dismutase glutathione peroxidase intoxication |
| url | https://www.mdpi.com/1648-9144/61/2/204 |
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