Discovery of 5-Methylthiazole-Thiazolidinone Conjugates as Potential Anti-Inflammatory Agents: Molecular Target Identification and In Silico Studies

Discovery of 5-Methylthiazole-Thiazolidinone Conjugates as Potential Anti-Inflammatory Agents: Molecular Target Identification and In Silico Studies

A series of previously synthesized 5-benzyliden-2-(5-methylthiazole-2-ylimino)thiazoli- din-4-one were evaluated for their anti-inflammatory activity on the basis of PASS predictive outcomes. The predictive compounds were found to demonstrate moderate to good anti-inflammatory activity, and some of...

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Bibliographic Details
Main Authors: Michelyne Haroun, Anthi Petrou, Christophe Tratrat, Aggeliki Kolokotroni, Maria Fesatidou, Panagiotis Zagaliotis, Antonis Gavalas, Katharigatta N. Venugopala, Nagaraja Sreeharsha, Anroop B. Nair, Heba Sadek Elsewedy, Athina Geronikaki
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Molecules
Subjects:
thiazole
thiazolidinone
anti-inflammatory activity
PASS
COX-1
COX-2
Online Access:https://www.mdpi.com/1420-3049/27/23/8137

Internet

https://www.mdpi.com/1420-3049/27/23/8137

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