Acid Microenvironment in Bone Sarcomas

Acid Microenvironment in Bone Sarcomas

In bone sarcomas, extracellular proton accumulation is an intrinsic driver of malignancy. Extracellular acidosis increases stemness, invasion, angiogenesis, metastasis, and resistance to therapy of cancer cells. It reprograms tumour-associated stroma into a protumour phenotype through the release of...

Full description

Bibliographic Details
Main Authors: Gemma Di Pompo, Margherita Cortini, Nicola Baldini, Sofia Avnet
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
bone sarcoma
extracellular acidosis
tumour microenvironment
tumour-associated stroma
acid-sensing ion channels
vacuolar-ATP-ase
Online Access:https://www.mdpi.com/2072-6694/13/15/3848

Internet

https://www.mdpi.com/2072-6694/13/15/3848

Similar Items