Comparative genomics and full-length Tprk profiling of Treponema pallidum subsp. pallidum reinfection.

Developing a vaccine against Treponema pallidum subspecies pallidum, the causative agent of syphilis, remains a public health priority. Syphilis vaccine design efforts have been complicated by lack of an in vitro T. pallidum culture system, prolific antigenic variation in outer membrane protein TprK...

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Bibliographic Details
Main Authors: Amin Addetia, Lauren C Tantalo, Michelle J Lin, Hong Xie, Meei-Li Huang, Christina M Marra, Alexander L Greninger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-04-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0007921