Design, Synthesis and Biological Activity of C3 Hemisynthetic Triterpenic Esters as Novel Antitrypanosomal Hits

Design, Synthesis and Biological Activity of C3 Hemisynthetic Triterpenic Esters as Novel Antitrypanosomal Hits

Abstract Research for innovative drugs is crucial to contribute to parasitic infections control and eradication. Inspired by natural antiprotozoal triterpenes, a library of 12 hemisynthetic 3‐O‐arylalkyl esters was derived from ursolic and oleanolic acids through one‐step synthesis. Compounds were t...

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Bibliographic Details
Main Authors: Laura Schioppa, Dr. Claire Beaufay, Dr. Natacha Bonneau, Dr. Marianela Sanchez, Dr. Cynthia Girardi, Dr. Aurélie Leverrier, Dr. Sergio Ortiz, Prof. Jorge Palermo, Prof. Jacques H. Poupaert, Prof. Joëlle Quetin‐Leclercq
Format: Article
Language:English
Published: Wiley-VCH 2021-09-01
Series:ChemistryOpen
Subjects:
antitrypanosomal drugs
biological activity
in vivo studies
synthesis design
terpenoids
Online Access:https://doi.org/10.1002/open.202100159

Internet

https://doi.org/10.1002/open.202100159

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