Single-cell spatial proteomic imaging for human neuropathology

Single-cell spatial proteomic imaging for human neuropathology

Abstract Neurodegenerative disorders are characterized by phenotypic changes and hallmark proteopathies. Quantifying these in archival human brain tissues remains indispensable for validating animal models and understanding disease mechanisms. We present a framework for nanometer-scale, spatial prot...

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Main Authors: Kausalia Vijayaragavan, Bryan J. Cannon, Dmitry Tebaykin, Marc Bossé, Alex Baranski, J. P. Oliveria, Syed A. Bukhari, Dunja Mrdjen, M. Ryan Corces, Erin F. McCaffrey, Noah F. Greenwald, Yari Sigal, Diana Marquez, Zumana Khair, Trevor Bruce, Mako Goldston, Anusha Bharadwaj, Kathleen S. Montine, R. Michael Angelo, Thomas J. Montine, Sean C. Bendall
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Acta Neuropathologica Communications
Online Access:https://doi.org/10.1186/s40478-022-01465-x

Internet

https://doi.org/10.1186/s40478-022-01465-x

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