Novel Labdane Diterpenes-Based Synthetic Derivatives: Identification of a Bifunctional Vasodilator That Inhibits Ca<sub>V</sub>1.2 and Stimulates K<sub>Ca</sub>1.1 Channels

Novel Labdane Diterpenes-Based Synthetic Derivatives: Identification of a Bifunctional Vasodilator That Inhibits Ca<sub>V</sub>1.2 and Stimulates K<sub>Ca</sub>1.1 Channels

Sesquiterpenes such as leucodin and the labdane-type diterpene manool are natural compounds endowed with remarkably in vitro vasorelaxant and in vivo hypotensive activities. Given their structural similarity with the sesquiterpene lactone (+)-sclareolide, this molecule was selected as a scaffold to...

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Bibliographic Details
Main Authors: Gabriele Carullo, Simona Saponara, Amer Ahmed, Beatrice Gorelli, Sarah Mazzotta, Alfonso Trezza, Beatrice Gianibbi, Giuseppe Campiani, Fabio Fusi, Francesca Aiello
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Marine Drugs
Subjects:
sclareolide
labdane
hypertension
vasorelaxant activity
Ca<sub>V</sub>1.2 channels
K<sub>Ca</sub>1.1 channels
Online Access:https://www.mdpi.com/1660-3397/20/8/515

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https://www.mdpi.com/1660-3397/20/8/515

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