Asymmetric bioreduction of β-ketoesters derivatives by Kluyveromyces marxianus: influence of molecular structure on the conversion and enantiomeric excess

Asymmetric bioreduction of β-ketoesters derivatives by Kluyveromyces marxianus: influence of molecular structure on the conversion and enantiomeric excess

ABSTRACT This study presents the bioreduction of six β-ketoesters by whole cells of Kluyveromyces marxianus and molecular investigation of a series of 13 β-ketoesters by hologram quantitative structure-activity relationship (HQSAR) in order to relate with conversion and enantiomeric excess of β-ster...

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Bibliographic Details
Main Authors: SIMONE S.S. OLIVEIRA, MURILO L. BELLO, CARLOS R. RODRIGUES, PAULA L. DE AZEVEDO, MARIA C.K.V. RAMOS, FRANCISCO R. DE AQUINO-NETO, SORELE B. FIAUX, LUIZA R.S. DIAS
Format: Article
Language:English
Published: Academia Brasileira de Ciências
Series:Anais da Academia Brasileira de Ciências
Subjects:
biocatalysis
β-ketoesters
β-hydroxyesters
HQSAR
whole cell bioreduction
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017005017104&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017005017104&lng=en&tlng=en

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