DNMT1-mediated DNA methylation in toll-like receptor 4 (TLR4) inactivates NF-κB signal pathway-triggered pyroptotic cell death and cellular inflammation to ameliorate lipopolysaccharides (LPS)-induced osteomyelitis

DNMT1-mediated DNA methylation in toll-like receptor 4 (TLR4) inactivates NF-κB signal pathway-triggered pyroptotic cell death and cellular inflammation to ameliorate lipopolysaccharides (LPS)-induced osteomyelitis

Toll-like receptor 4 (TLR4) plays a critical role in various human diseases, and was associated with pyroptotic cell death and inflammatory responses. DNA methylation, which has stable and reversible properties, has been reported to alter the expression of target genes, including TLR4. However, the...

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Bibliographic Details
Main Authors: Muguo Song, Junyi Li, Jian Sun, Xiaoyong Yang, Xijiao Zhang, Kehan Lv, Yongqing Xu, Jian Shi
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Molecular and Cellular Probes
Subjects:
Osteomyelitis
Toll-like receptor 4
DNA methylation
Pyroptosis
Inflammatory response
Online Access:http://www.sciencedirect.com/science/article/pii/S0890850823000312

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http://www.sciencedirect.com/science/article/pii/S0890850823000312

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