The bright side of fibroblasts: molecular signature and regenerative cues in major organs
Abstract Fibrosis is a pathologic process characterized by the replacement of parenchymal tissue by large amounts of extracellular matrix, which may lead to organ dysfunction and even death. Fibroblasts are classically associated to fibrosis and tissue repair, and seldom to regeneration. However, ac...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-08-01
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| Series: | npj Regenerative Medicine |
| Online Access: | https://doi.org/10.1038/s41536-021-00153-z |
| _version_ | 1797743987668287488 |
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| author | Rita N. Gomes Filipa Manuel Diana S. Nascimento |
| author_facet | Rita N. Gomes Filipa Manuel Diana S. Nascimento |
| author_sort | Rita N. Gomes |
| collection | DOAJ |
| description | Abstract Fibrosis is a pathologic process characterized by the replacement of parenchymal tissue by large amounts of extracellular matrix, which may lead to organ dysfunction and even death. Fibroblasts are classically associated to fibrosis and tissue repair, and seldom to regeneration. However, accumulating evidence supports a pro-regenerative role of fibroblasts in different organs. While some organs rely on fibroblasts for maintaining stem cell niches, others depend on fibroblast activity, particularly on secreted molecules that promote cell adhesion, migration, and proliferation, to guide the regenerative process. Herein we provide an up-to-date overview of fibroblast-derived regenerative signaling across different organs and discuss how this capacity may become compromised with aging. We further introduce a new paradigm for regenerative therapies based on reverting adult fibroblasts to a fetal/neonatal-like phenotype. |
| first_indexed | 2024-03-12T15:03:23Z |
| format | Article |
| id | doaj.art-6346be79c53e483da95b01693d5584a5 |
| institution | Directory Open Access Journal |
| issn | 2057-3995 |
| language | English |
| last_indexed | 2024-03-12T15:03:23Z |
| publishDate | 2021-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Regenerative Medicine |
| spelling | doaj.art-6346be79c53e483da95b01693d5584a52023-08-13T11:07:18ZengNature Portfolionpj Regenerative Medicine2057-39952021-08-016111210.1038/s41536-021-00153-zThe bright side of fibroblasts: molecular signature and regenerative cues in major organsRita N. Gomes0Filipa Manuel1Diana S. Nascimento2Instituto de Investigação e Inovação em Saúde (i3S), Universidade do PortoInstituto de Investigação e Inovação em Saúde (i3S), Universidade do PortoInstituto de Investigação e Inovação em Saúde (i3S), Universidade do PortoAbstract Fibrosis is a pathologic process characterized by the replacement of parenchymal tissue by large amounts of extracellular matrix, which may lead to organ dysfunction and even death. Fibroblasts are classically associated to fibrosis and tissue repair, and seldom to regeneration. However, accumulating evidence supports a pro-regenerative role of fibroblasts in different organs. While some organs rely on fibroblasts for maintaining stem cell niches, others depend on fibroblast activity, particularly on secreted molecules that promote cell adhesion, migration, and proliferation, to guide the regenerative process. Herein we provide an up-to-date overview of fibroblast-derived regenerative signaling across different organs and discuss how this capacity may become compromised with aging. We further introduce a new paradigm for regenerative therapies based on reverting adult fibroblasts to a fetal/neonatal-like phenotype.https://doi.org/10.1038/s41536-021-00153-z |
| spellingShingle | Rita N. Gomes Filipa Manuel Diana S. Nascimento The bright side of fibroblasts: molecular signature and regenerative cues in major organs npj Regenerative Medicine |
| title | The bright side of fibroblasts: molecular signature and regenerative cues in major organs |
| title_full | The bright side of fibroblasts: molecular signature and regenerative cues in major organs |
| title_fullStr | The bright side of fibroblasts: molecular signature and regenerative cues in major organs |
| title_full_unstemmed | The bright side of fibroblasts: molecular signature and regenerative cues in major organs |
| title_short | The bright side of fibroblasts: molecular signature and regenerative cues in major organs |
| title_sort | bright side of fibroblasts molecular signature and regenerative cues in major organs |
| url | https://doi.org/10.1038/s41536-021-00153-z |
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