ADAMTS13, VWF, and Endotoxin Are Interrelated and Associated with the Severity of Liver Cirrhosis via Hypercoagulability

ADAMTS13, VWF, and Endotoxin Are Interrelated and Associated with the Severity of Liver Cirrhosis via Hypercoagulability

ADAMTS13 specifically cleaves the multimeric von Willebrand factor (VWF), and an imbalance between ADAMTS13 activity (ADAMTS13:AC) and VWF antigen (VWF:Ag) levels is associated with the severity of liver cirrhosis (LC). However, the reason for this imbalance in patients with LC is unknown. This stud...

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Bibliographic Details
Main Authors: Hiroaki Takaya, Tadashi Namisaki, Shohei Asada, Satoshi Iwai, Takahiro Kubo, Junya Suzuki, Masahide Enomoto, Yuki Tsuji, Yukihisa Fujinaga, Norihisa Nishimura, Yasuhiko Sawada, Kosuke Kaji, Hideto Kawaratani, Kei Moriya, Takemi Akahane, Masanori Matsumoto, Hitoshi Yoshiji
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Journal of Clinical Medicine
Subjects:
ADAMTS13
von Willebrand factor
endotoxin
liver cirrhosis
hypercoagulability
Online Access:https://www.mdpi.com/2077-0383/11/7/1835

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https://www.mdpi.com/2077-0383/11/7/1835

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