CCN1/Integrin α<sub>5</sub>β<sub>1</sub> Instigates Free Fatty Acid-Induced Hepatocyte Lipid Accumulation and Pyroptosis through NLRP3 Inflammasome Activation

Hyperlipidemia with high blood levels of free fatty acids (FFA) is the leading cause of non-alcoholic steatohepatitis. CCN1 is a secreted matricellular protein that drives various cellular functions, including proliferation, migration, and differentiation. However, its role in mediating FFA-induced...

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Bibliographic Details
Main Authors: Qinyu Yao, Jia Liu, Qi Cui, Tingting Jiang, Xinya Xie, Xiong Du, Ziwei Zhao, Baochang Lai, Lei Xiao, Nanping Wang
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Nutrients
Subjects:
Online Access:https://www.mdpi.com/2072-6643/14/18/3871