Understanding the role of mechanics in nucleocytoplasmic transport
Cell nuclei are submitted to mechanical forces, which in turn affect nuclear and cell functions. Recent evidence shows that a crucial mechanically regulated nuclear function is nucleocytoplasmic transport, mediated by nuclear pore complexes (NPCs). Mechanical regulation occurs at two levels: first,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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AIP Publishing LLC
2022-06-01
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| Series: | APL Bioengineering |
| Online Access: | http://dx.doi.org/10.1063/5.0076034 |
| _version_ | 1818466071654432768 |
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| author | Ion Andreu Ignasi Granero-Moya Sergi Garcia-Manyes Pere Roca-Cusachs |
| author_facet | Ion Andreu Ignasi Granero-Moya Sergi Garcia-Manyes Pere Roca-Cusachs |
| author_sort | Ion Andreu |
| collection | DOAJ |
| description | Cell nuclei are submitted to mechanical forces, which in turn affect nuclear and cell functions. Recent evidence shows that a crucial mechanically regulated nuclear function is nucleocytoplasmic transport, mediated by nuclear pore complexes (NPCs). Mechanical regulation occurs at two levels: first, by force application to the nucleus, which increases NPC permeability likely through NPC stretch. Second, by the mechanical properties of the transported proteins themselves, as mechanically labile proteins translocate through NPCs faster than mechanically stiff ones. In this perspective, we discuss this evidence and the associated mechanisms by which mechanics can regulate the nucleo-cytoplasmic partitioning of proteins. Finally, we analyze how mechanical regulation of nucleocytoplasmic transport can provide a systematic approach to the study of mechanobiology and open new avenues both in fundamental and applied research. |
| first_indexed | 2024-04-13T20:54:38Z |
| format | Article |
| id | doaj.art-634792b63b284e619a59005e4a4bd31c |
| institution | Directory Open Access Journal |
| issn | 2473-2877 |
| language | English |
| last_indexed | 2024-04-13T20:54:38Z |
| publishDate | 2022-06-01 |
| publisher | AIP Publishing LLC |
| record_format | Article |
| series | APL Bioengineering |
| spelling | doaj.art-634792b63b284e619a59005e4a4bd31c2022-12-22T02:30:23ZengAIP Publishing LLCAPL Bioengineering2473-28772022-06-0162020901020901-610.1063/5.0076034Understanding the role of mechanics in nucleocytoplasmic transportIon Andreu0Ignasi Granero-Moya1Sergi Garcia-Manyes2Pere Roca-Cusachs3 Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Technology (BIST), 08028 Barcelona, Spain Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Technology (BIST), 08028 Barcelona, Spain Department of Physics, Randall Centre for Cell and Molecular Biophysics, King's College London, WC2R 2LS London, United Kingdom; Single Molecule Mechanobiology Laboratory, The Francis Crick Institute, NW1 1AT London, United Kingdom Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Technology (BIST), 08028 Barcelona, SpainCell nuclei are submitted to mechanical forces, which in turn affect nuclear and cell functions. Recent evidence shows that a crucial mechanically regulated nuclear function is nucleocytoplasmic transport, mediated by nuclear pore complexes (NPCs). Mechanical regulation occurs at two levels: first, by force application to the nucleus, which increases NPC permeability likely through NPC stretch. Second, by the mechanical properties of the transported proteins themselves, as mechanically labile proteins translocate through NPCs faster than mechanically stiff ones. In this perspective, we discuss this evidence and the associated mechanisms by which mechanics can regulate the nucleo-cytoplasmic partitioning of proteins. Finally, we analyze how mechanical regulation of nucleocytoplasmic transport can provide a systematic approach to the study of mechanobiology and open new avenues both in fundamental and applied research.http://dx.doi.org/10.1063/5.0076034 |
| spellingShingle | Ion Andreu Ignasi Granero-Moya Sergi Garcia-Manyes Pere Roca-Cusachs Understanding the role of mechanics in nucleocytoplasmic transport APL Bioengineering |
| title | Understanding the role of mechanics in nucleocytoplasmic transport |
| title_full | Understanding the role of mechanics in nucleocytoplasmic transport |
| title_fullStr | Understanding the role of mechanics in nucleocytoplasmic transport |
| title_full_unstemmed | Understanding the role of mechanics in nucleocytoplasmic transport |
| title_short | Understanding the role of mechanics in nucleocytoplasmic transport |
| title_sort | understanding the role of mechanics in nucleocytoplasmic transport |
| url | http://dx.doi.org/10.1063/5.0076034 |
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