[68Ga]Ga-PSMA PET/MRI, histological PSMA expression and preliminary experience with [177Lu]Lu-PSMA therapy in relapsing high-grade glioma

[68Ga]Ga-PSMA PET/MRI, histological PSMA expression and preliminary experience with [177Lu]Lu-PSMA therapy in relapsing high-grade glioma

PurposeHigh-grade gliomas (HGG) are still associated with a dismal prognosis. Prostate specific membrane antigen (PSMA) is discussed as a theranostic target for PSMA-directed radioligand therapy ([177Lu]Lu-PSMA RLT). Here, we report on the correlation of [68Ga]Ga-PSMA uptake with histological PSMA e...

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Bibliographic Details
Main Authors: Peter Truckenmueller, Josefine Graef, Michael Scheel, Peter Vajkoczy, David Capper, David Kaul, Christian Furth, Holger Amthauer, Winfried Brenner, Julia Sophie Onken
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Oncology
Subjects:
IHC PSMA expression
relapsing malignant glioma
[177Lu]Lu-PSMA therapy
[68Ga]Ga-PSMA PET/MRI
individualized treatment
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.980058/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.980058/full

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