Novel CD28 antagonist mPEG PV1-Fab' mitigates experimental autoimmune uveitis by suppressing CD4+ T lymphocyte activation and IFN-γ production.

Novel CD28 antagonist mPEG PV1-Fab' mitigates experimental autoimmune uveitis by suppressing CD4+ T lymphocyte activation and IFN-γ production.

Autoimmune Uveitis is an important chronic inflammatory disease and a leading cause of impaired vision and blindness. This ocular autoimmune disorder is mainly mediated by T CD4+ lymphocytes poising a TH1 phenotype. Costimulatory molecules are known to play an important role on T cell activation and...

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Main Authors: Pedro Henrique Papotto, Eliana Blini Marengo, Luiz Roberto Sardinha, Karina Inácio Carvalho, Ana Eduarda Zulim de Carvalho, Sheyla Castillo-Mendez, Carina Calixto Jank, Bernard Vanhove, Anna Carla Goldberg, Luiz Vicente Rizzo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5331984?pdf=render

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http://europepmc.org/articles/PMC5331984?pdf=render

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