Synthesis, Self-Assembly in Crystalline Phase and Anti-Tumor Activity of 2-(2-/4-Hydroxybenzylidene)thiazolo[3,2-<i>a</i>]pyrimidines

Synthesis, Self-Assembly in Crystalline Phase and Anti-Tumor Activity of 2-(2-/4-Hydroxybenzylidene)thiazolo[3,2-<i>a</i>]pyrimidines

A series of new thiazolo[3,2-<i>a</i>]pyrimidines different by aryl substituents in 2 and 5 positions are synthesized and characterized in solution as well as in the crystalline phase using <sup>1</sup>H and <sup>13</sup>C NMR-, IR-spectroscopies, mass-spectrometr...

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Bibliographic Details
Main Authors: Artem S. Agarkov, Anna A. Nefedova, Elina R. Gabitova, Alexander S. Ovsyannikov, Syumbelya K. Amerhanova, Anna P. Lyubina, Alexandra D. Voloshina, Pavel V. Dorovatovskii, Igor A. Litvinov, Svetlana E. Solovieva, Igor S. Antipin
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Molecules
Subjects:
thiazolo[3,2-<i>a</i>]pyrimidines
solid-state structure
non-covalent interactions
cytotoxicity
antitumor agents
multiplex analysis of DNA markers of genotoxicity
Online Access:https://www.mdpi.com/1420-3049/27/22/7747

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https://www.mdpi.com/1420-3049/27/22/7747

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