Dengue Virus Infection Alters Inter-Endothelial Junctions and Promotes Endothelial–Mesenchymal-Transition-like Changes in Human Microvascular Endothelial Cells

Dengue Virus Infection Alters Inter-Endothelial Junctions and Promotes Endothelial–Mesenchymal-Transition-like Changes in Human Microvascular Endothelial Cells

Dengue virus (DENV) is a pathogenic arbovirus that causes human disease. The most severe stage of the disease (severe dengue) is characterized by vascular leakage, hypovolemic shock, and organ failure. Endothelial dysfunction underlies these phenomena, but the causal mechanisms of endothelial dysfun...

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Bibliographic Details
Main Authors: Manuela Escudero-Flórez, David Torres-Hoyos, Yaneth Miranda-Brand, Ryan L. Boudreau, Juan Carlos Gallego-Gómez, Miguel Vicente-Manzanares
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Viruses
Subjects:
dengue virus
endothelial cells
cell migration
c-ABL
EMT
EndMT
Online Access:https://www.mdpi.com/1999-4915/15/7/1437

Internet

https://www.mdpi.com/1999-4915/15/7/1437

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