Case Report: Fatal Complications of BK Virus-Hemorrhagic Cystitis and Severe Cytokine Release Syndrome Following BK Virus-Specific T-Cells

Case Report: Fatal Complications of BK Virus-Hemorrhagic Cystitis and Severe Cytokine Release Syndrome Following BK Virus-Specific T-Cells

BK virus (BKV)-hemorrhagic cystitis (HC) is a well-known and rarely fatal complication of hematopoietic stem cell transplantation (HSCT). Treatment for BKV-HC is limited, but virus-specific T-cells (VST) represent a promising therapeutic option feasible for use posttransplant. We report on the case...

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Bibliographic Details
Main Authors: Elizabeth M. Holland, Corina Gonzalez, Elliot Levy, Vladimir A. Valera, Heather Chalfin, Jacquelyn Klicka-Skeels, Bonnie Yates, David E. Kleiner, Colleen Hadigan, Hema Dave, Haneen Shalabi, Dennis D. Hickstein, Helen C. Su, Michael Grimley, Alexandra F. Freeman, Nirali N. Shah
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Immunology
Subjects:
DOCK8 immunodeficiency syndrome
HSCT = hematopoietic stem cell transplant
BK virus associated hemorrhagic cystitis
virus specific T-cells
cytokine release syndrome
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.801281/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.801281/full

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