GTP binding to translation factor eIF2B stimulates its guanine nucleotide exchange activity

GTP binding to translation factor eIF2B stimulates its guanine nucleotide exchange activity

Summary: eIF2B is the guanine nucleotide exchange factor (GEF) required for cytoplasmic protein synthesis initiation in eukaryotes and its regulation within the integrated stress response (ISR). It activates its partner factor eIF2, thereby promoting translation initiation. Here we provide evidence...

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Bibliographic Details
Main Authors: Christopher J. Kershaw, Martin D. Jennings, Francesco Cortopassi, Margherita Guaita, Hawra Al-Ghafli, Graham D. Pavitt
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:iScience
Subjects:
Biological sciences
Molecular biology
Cell biology
Biomechanics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221014255

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http://www.sciencedirect.com/science/article/pii/S2589004221014255

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