Dynamics of necroptosis in kidney ischemia-reperfusion injury

Necroptosis, a pathway of regulated necrosis, involves recruitment and activation of RIPK1, RIPK3 and MLKL, leading to cell membrane rupture, cell death and release of intracellular contents causing further injury and inflammation. Necroptosis is believed to play an important role in the pathogenesi...

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Bibliographic Details
Main Authors: Aspasia Pefanis, Anjan K. Bongoni, Jennifer L. McRae, Evelyn J. Salvaris, Nella Fisicaro, James M. Murphy, Francesco L. Ierino, Peter J. Cowan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1251452/full