Reduced miR-659-3p levels correlate with progranulin increase in hypoxic conditions: implications for frontotemporal dementia.

Reduced miR-659-3p levels correlate with progranulin increase in hypoxic conditions: implications for frontotemporal dementia.

Progranulin (PGRN) is a secreted protein expressed ubiquitously throughout the body, including the brain, where it localizes in neurons and activated microglia. Loss-of-function mutations in the GRN gene are an important cause of familial Frontotemporal Lobar Degeneration (FTLD). PGRN has a neurotro...

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Bibliographic Details
Main Authors: Paola ePiscopo, Margherita eGrasso, Francesca eFontana, Alessio eCrestini, Maria ePuopolo, Valerio eDel Vescovo, Aldina eVenerosi, Gemma eCalamandrei, Sebastian F Vencken, Catherine M Greene, Annamaria eConfaloni, Michela Alessandra Denti
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Frontotemporal Dementia
Rats
hypoxia
progranulin
SK-N-BE
miR-659-3p
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00031/full

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http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00031/full

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