GLI2 regulates TGF-β1 in human CD4+ T cells: implications in cancer and HIV pathogenesis.

Elevated levels of the immunoregulatory cytokine TGF-β1 in cancer and HIV infection have been linked to the suppression of protective immune responses. The transcriptional regulation of TGF-β1 is complex and still not completely understood. We report here for the first time that the transcription fa...

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Bibliographic Details
Main Authors: Robert L Furler, Christel H Uittenbogaart
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3409217?pdf=render