Sequence-Specific Features of Short Double-Strand, Blunt-End RNAs Have RIG-I- and Type 1 Interferon-Dependent or -Independent Anti-Viral Effects

Sequence-Specific Features of Short Double-Strand, Blunt-End RNAs Have RIG-I- and Type 1 Interferon-Dependent or -Independent Anti-Viral Effects

Pathogen-associated molecular patterns, including cytoplasmic DNA and double-strand (ds)RNA trigger the induction of interferon (IFN) and antiviral states protecting cells and organisms from pathogens. Here we discovered that the transfection of human airway cell lines or non-transformed fibroblasts...

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Bibliographic Details
Main Authors: Abhilash Kannan, Maarit Suomalainen, Romain Volle, Michael Bauer, Marco Amsler, Hung V. Trinh, Stefano Vavassori, Jana Pachlopnik Schmid, Guilherme Vilhena, Alberto Marín-González, Ruben Perez, Andrea Franceschini, Christian von Mering, Silvio Hemmi, Urs F. Greber
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Viruses
Subjects:
short double-strand blunt-end RNA
RIG-I
interferon
DNA virus
RNA virus
RNA therapy
Online Access:https://www.mdpi.com/1999-4915/14/7/1407

Internet

https://www.mdpi.com/1999-4915/14/7/1407

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