Identification of mechanics-responsive osteocyte signature in osteoarthritis subchondral bone

Identification of mechanics-responsive osteocyte signature in osteoarthritis subchondral bone

Aims: Osteoarthritis (OA) is a common degenerative joint disease. The osteocyte transcriptome is highly relevant to osteocyte biology. This study aimed to explore the osteocyte transcriptome in subchondral bone affected by OA. Methods: Gene expression profiles of OA subchondral bone were used to ide...

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Bibliographic Details
Main Authors: Jun Zhou, Zhiyi He, Jiarui Cui, Xiaoling Liao, Hui Cao, Yo Shibata, Takashi Miyazaki, Jiaming Zhang
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2022-06-01
Series:Bone & Joint Research
Subjects:
osteoarthritis
subchondral bone
mechanics
osteocyte
transcriptome
osteocytes
osteoarthritis (oa)
bone remodelling
transforming growth factor beta
tibial plateaus
lesioned
lateral tibial plateaus
extracellular matrix
rna
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.116.BJR-2021-0436.R1

Internet

https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.116.BJR-2021-0436.R1

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