Proteasome inhibition paradoxically degrades gain-of-function mutant p53 R273H in NSCLC and could have therapeutic implications

Proteasome inhibition paradoxically degrades gain-of-function mutant p53 R273H in NSCLC and could have therapeutic implications

Lung cancer is the leading cause of cancer mortality. Despite therapeutic advances in recent years, new treatment strategies are needed to improve outcomes of lung cancer patients. Mutant p53 is prevalent in lung cancers and drives several hallmarks of cancer through a gain-of-function oncogenic pro...

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Bibliographic Details
Main Authors: Eziafa I. Oduah, Susan T. Sharfstein, Nagashree Seetharamu, Steven R. Grossman, Larisa Litovchick
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Oncology
Subjects:
NSCLC
proteasome
TP53
mutant p53
proteasome inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1363543/full

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https://www.frontiersin.org/articles/10.3389/fonc.2024.1363543/full

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