Rapid Generation of Circulating and Mucosal Decoy Human ACE2 using mRNA Nanotherapeutics for the Potential Treatment of SARS‐CoV‐2

Rapid Generation of Circulating and Mucosal Decoy Human ACE2 using mRNA Nanotherapeutics for the Potential Treatment of SARS‐CoV‐2

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) can cause lethal pulmonary damage in humans. It contains spike proteins on its envelope that bind to human angiotensin‐converting enzyme 2 (hACE2) expressed on airway cells, enabling entry of the virus, and causing infection. The...

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Bibliographic Details
Main Authors: Jeonghwan Kim, Antony Jozic, Anindit Mukherjee, Dylan Nelson, Kevin Chiem, Md Siddiqur Rahman Khan, Jordi B. Torrelles, Luis Martinez‐Sobrido, Gaurav Sahay
Format: Article
Language:English
Published: Wiley 2022-12-01
Series:Advanced Science
Subjects:
COVID‐19
gene therapy
human soluble ACE2
lipid nanoparticles
messenger RNA
Online Access:https://doi.org/10.1002/advs.202202556

Internet

https://doi.org/10.1002/advs.202202556

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